Open source physiological data and physiological-based kinetic model code for the chicken (Gallus gallus domesticus)

This excel file and mode code (DOI:10.5281/zenodo.3603114) provides:

1. Physiological parameters and associated inter-individual variability (sample size, mean, coefficient of variation,) for chicken (Gallus gallus domesticus). These physiological parameters were estimated based on the results of extensive literature searches and specific experimental data described in Lautz et al., (2020).

2. An R code for the generic chicken physiologically based model as well as the “soboljansen” code to carry out sensitivity analysis using sobol plots. The code for the generic model allows to run:

a. A deterministic PBK model which represents only a single animal.

b. A probabilistic PBK model to simulate individual differences in physiological parameters within a population. Sensitivity analyses can be performed to identify which parameters have the most impact on the model’s outputs. Predictions can be compared with experimental data. The model can be used to assess the influence of physiological parameters on the kinetics of chemicals. For PBK modelling purposes, species and chemical specific kinetics (e.g clearance, absorption rate, etc…) should be provided by the user.

The full data collection and implementation of the models using case studies are described in (Lautz et al., 2020).

The dataset providing the physiological parameters is available in Excel.
The R code is presented as meta data to be implemented in R.