five

Unpublished and published liraglutide studies in humans

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<strong>Unpublished and published liraglutide studies in humans - Completed before Jan 2011</strong> Unpublished (n=37): 68.5%<br>Published (n=17): 31.5% ----&gt; 3.1 papers per registry ___________________________________________ Google Drive spreadsheet ---&gt; Open Settings --&gt; Anybody can post comments 5th URL __________________________________________ <em>"In the Novo Nordisk study, the rats treated with liraglutide showed increased ductal proliferation and acinar to ductal metaplasia. One rat treated with exenatide had a “hemorrhagic pancreas” at necropsy with 'moderate apoptosis-like necrosis, minimal inflammatory infiltration and slight hemorrhage/edema.”13Although the pancreases did not increase in weight, the incretin treated rats had “significantly higher” levels of pancreatic amylase. Three of the liraglutide treated animals died from a 'single erroneous dosing.'</em> <em>A spokeswoman from Novo Nordisk told the BMJ, 'Importantly, the study did not find any abnormalities in the pancreas associated with liraglutide treatment.'"</em> <strong>Cohen D. Has pancreatic damage from glucagon suppressing diabetes drugs been underplayed? BMJ 2013; 346.</strong> - 6th URL - Liraglutide findings in monkeys added to the fileset - Full paper available in this fileset ______________________________________<br>
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figshare
创建时间:
2016-01-19
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