Mapping of histone modifications in aged hematopoietic stem cells (HSCs)
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=54505a6650a9d6c66726eff1ccd9c874
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资源简介：
The decline of hematopoietic stem cell (HSC) function upon aging contributes to senescent immune remodeling and to leukemia pathogenesis. Aged HSCs show epigenetic alterations affecting DNA methylation, histone modifications, and show a reduction in the polar distribution of histone 4 lysine 16 acetylation (H4K16ac). Here, we determined the deposition patterns of H4K16ac in young, aged and re-juvenated HSCs using ChIP-seq.
提供机构：
German Cancer Research Center
创建时间：
2022-02-20
