WP4249 - Hedgehog signaling - Homo sapiens
收藏NIAID Data Ecosystem2026-05-02 收录
下载链接：
https://www.ndexbio.org/viewer/networks/b330559f-5c6e-11ec-b3be-0ac135e8bacf
下载链接
链接失效反馈官方服务：
资源简介：
In the absence of the Hh ligand, the receptor PTCH (Patched) acts to prevent high expression and activity of SMO (Smoothened). When Hh is bound, the repression of SMO is relieved which leads to activation of the GLI transcription factors: activators Gli1 and Gli2 and repressor Gli3. Activated GLI then controls the transcription of hedgehog target genes.
Pathway adapted from [KEGG](http://www.genome.jp/kegg-bin/show_pathway?hsa04340).
创建时间：
2025-04-17
