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CD137-CIS IO

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158041
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CD137 cis-costimulation is superior to trans-costimulation at inducing transcriptomic differences in T-cell proliferation and DNA repair programs We used microarrays to detail differentially expressed genes of cis- and trans CD137-costimulated CD8 T cells with respect to CD3-TCR stimulation Human CD8 T cells were purified from peripheral blood of 3 healthy donors. CD8 T cells were then activated with mAb coated microbeads for 32 hours. mRNA was then extracted and mRNA expression profile was determine using Affymetrix human Clariom S assay
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2021-12-28
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