Gene expression data from the heart during regeneration in a zebrafish model of heart failure

Heart Failure (HF) remains the leading cause of mortality and morbidity globally. Novel therapeutic targets to tackle this pandemic are in dire need. Zebrafish, a vertebrate whose heart shares many physiological similarities to the human heart, are able to naturally undergo cardiac regeneration following HF. We used microarrays to analyse gene expression during cardiac regeneration following heart failure Heart failure was induced in adult zebrafish using phenylhydrazine (PHZ, anaemia inducer) treatment for 5 weeks followed by a regeneration period of 9 days without PHZ. Whole-genome microarray analysis was performed in heart samples at the end of the PHZ treatment and at different time-points thereafter (2, 5 and 9 days after PHZ treatment discontinuation). Gene regulation patterns were characterized using bioinformatics.