Data from: Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? A retrospective chart review of patients presenting to a tertiary care centre in Lebanon

Objective: Most sepsis studies have looked at the general population. The
aim of this study is to report on the characteristics, treatment and
hospital mortality of patients with cancer diagnosed with sepsis or septic
shock. Setting: A single-centre retrospective study at a tertiary care
centre looking at patients with cancer who presented to our tertiary
hospital with sepsis, septic shock or bacteraemia between 2010 and 2015.
Participants: 176 patients with cancer were compared with 176 cancer-free
controls. Primary and secondary outcomes: The primary outcome of this
study was the in hospital mortality in both cohorts. Secondary outcomes
included patient demographics, emergency department (ED) vital signs and
parameters of resuscitation along with laboratory work. Results: A total
of 352 patients were analysed. The mean age at presentation for the cancer
group was 65.39±15.04 years, whereas the mean age for the control group
was 74.68±14.04 years (p<0.001). In the cancer cohort the
respiratory system was the most common site of infection (37.5%) followed
by the urinary system (26.7%), while in the cancer-free arm, the urinary
system was the most common site of infection (40.9%). intravenous fluid
replacement for the first 24 hours was higher in the cancer cohort. ED,
intensive care unit and general practice unit length of stay were
comparable in both the groups. 95 (54%) patients with cancer died compared
with 75 (42.6%) in the cancer-free group. The 28-day hospital mortality in
the cancer cohort was 87 (49.4%) vs 46 (26.1%) in the cancer-free cohort
(p=0.009). Patients with cancer had a 2.320 (CI 95% 1.225 to 4.395,
p=0.010) odds of dying compared with patients without cancer in the
setting of sepsis. Conclusions: This is the first study looking at an
in-depth analysis of sepsis in the specific oncology population. Despite
aggressive care, patients with cancer have higher hospital mortality than
their cancer-free counterparts while adjusting for all other variables.