High (5X) 5-methyltetrahydrofolate (MTHF) vs folic acid (FA) pregnancy diets on hypothalamic gene expression of Wistar rat dams upon birth.

Conclusion: This study provides novel insight towards the differential effects of folate form during pregnancy on regulating dynamic changes in gene expression of the maternal brain upon birth. The results of our study may led to hypothesis testing to identify novel candidate genes and pathways targeted by folate during pregnancy that have a role in disease on-set and/or prevention.