Transcriptional profile of cardiac aging and its modification by insulin signaling (CBX72). unidentified

The objects of this study were to characterize aging process of heart, and to test if suppression of insulin/IGF-1 signaling modifies cardiac aging. Young (3-month old) and old (20 to 24-month old), transgenic mice (expressing a cardiac-restricted dominant-negative mutant of PI3K) and non-transgenic littermates were examined. We analyzed gene expression using whole-genome microarrays on heart samples (n=6 for each group). A comparison of the gene expression profile among 4 groups was performed with special attention to the genes affected by aging or by suppression of insulin signaling.