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Expression data from the complex I mutant gas-1 (fc21) C. elegans worms in comparison to wildtype N2 Bristol worm and under the inluence of antioxidant drug treatment

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE66680
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We studied genome-wide expression profiles of C. elegans young adult worms, complex I mutant gas-1(fc21) compare to the wild type N2 Bristol worm and the effect of different antioxidant drug treatment on the gene expression profile in gas-1(fc21). 4 biological replicates of wildtype (N2 Bristol) synchronized worms grown on OP50 bacteria, 4 biological replicates of the complex I mutant C. elegans synchronized young adults and 4 biological replicates of synchronized complex I mutant worm treated with the different antioxidant drugs were used as sources of total RNA, each for hybridization to a single Affymetrix whole-genome microarray. Comparison of the data was intended to reveal causes of different antioxidant drug treatment on gene expresssion profile in the complex I mutant gas-1(fc21) worms. These array data are part of a bigger project of antioxidant drug effects that also includes RNAseq data deposited in SRA as Bioproject PRJNA2751152. Wild-type vs complex I mutant vs complex I mutant treated with antioxidant drug comparison as a method for studying the possible beneficial effect of these drugs.
创建时间:
2017-03-03
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