Supporting Information for DO Lifespan Interventions Study

In this study, we report the effects of graded levels of CR and IF initiated during adulthood (at 6 months of age) on the health and lifespan of a large cohort of DO mice. We utilized a unique cohort comprising close to 1,000 genetically diverse and genotyped female mice in which we longitudinally profiled 194 traits across 11 categories from the age of 3 months to death.