Mouse Models of Human Cancer Database

The Mouse Tumor Biology (MTB) Database supports the use of the mouse as a model system of human cancers by providing access to information on and data for: spontaneous and induced tumors in mice, genetically defined mice (inbred, hybrid, mutant, and genetically engineered strains of mice) in which tumors arise, genetic factors associated with tumor susceptibility in mice, somatic genetic-mutations observed in tumors, and Patient Derived Xenograft (PDX) models.

小鼠肿瘤生物学（Mouse Tumor Biology，MTB）数据库通过提供以下各类信息与数据，为以小鼠作为人类癌症研究模式动物的应用提供支撑：小鼠自发性与诱发性肿瘤、可发生肿瘤的基因限定型小鼠（涵盖近交系、杂交系、突变系及基因工程改造小鼠品系）、与小鼠肿瘤易感性相关的遗传因素、肿瘤中检出的体细胞遗传突变，以及患者来源异种移植（Patient Derived Xenograft，PDX）模型。

搜集汇总

背景与挑战

背景概述

该数据库是一个全面且由专家管理的资源，专门收集多样的人类癌症小鼠模型。它重点关注自发性与诱导性肿瘤、基因定义的癌症小鼠模型（如近交系、突变系等）以及患者来源的异种移植（PDX）模型。