Additional file 3 of DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Additional file 3. Table S1. Sample sizes and final numbers of complete twin pairs included in 450K and EPIC platforms for EWAS designs on PDS and PA. Table S2. Details on univariate twin modelling results on the 14 CpG sites. The estimates for total phenotypic variance and mean, as well as the coefficients of the covariates (age and sex), are shown. Table S3. Individual associations and within-twin pair methylation differences of the 58 CpG sites identified in the EWAS. Table S4. Results of qualitative and quantitative sex differences for omnibus tests and specific parameters on CpG sites. Table S5. CpG sites associated with pubertal development scale (PDS) with a standardised effect size > |0.13| stratified by the model. Table S6. CpG sites associated with pubertal age (PA) in males or females with a standardised effect size > |0.13|. Table S7. CpG sites associated with pubertal development scale (PDS) or pubertal age (PA) with a standardised effect size > |0.13| enriched in canonical pathways from the Ingenuity Pathway Analysis. Table S8. CpG sites associated with pubertal development scale (PDS) or pubertal age (PA) with a standardised effect size > |0.13| enriched in diseases and functions from the Ingenuity Pathway Analysis. Table S9. IPA results on meQTLs (p < 5 x 10-8) of CpG sites associated with pubertal development scale (PDS) or pubertal age (PA). Both the Ingenuity Canonical pathways and diseases/functions annotations are included.