Dataset of figures and summary tables supporting the review: "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury"

This dataset contains all summary figures and comprehensive table files directly associated with the review article titled "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury". This review systematically summarizes recent advances in using hair follicle neural crest stem cells (hfNCSCs) and their exosomes for peripheral nerve injury (PNI) repair, with a focus on molecular mechanisms and translational applications.
This dataset does not contain primary experimental data. Instead, it provides derivative content generated from the systematic analysis of existing literature, aiming to present domain knowledge in a clear and visual format. It includes:
PRISMA Flow Diagram:
Formats: SVG (editable vector)
Details: Documents literature screening process across PubMed and CNKI databases, with exclusion criteria and final inclusion count (n=89 studies).
Comprehensive Comparison Tables:
Table 1: A comparative analysis table of the characteristics of hfNCSCs versus other stem cell types (e.g., mesenchymal stem cells), adapted from literature.
Table 2: A comparison table of mainstream exosome isolation techniques (e.g., ultracentrifugation, size-exclusion chromatography, polymer-based precipitation), detailing their principles, advantages, and limitations.
Table 3: A summary table of the therapeutic applications and outcomes of exosomes derived from various stem cell sources in different PNI animal models.
Mechanistic Schematic Diagrams:
Figure 1: A schematic diagram illustrating the mechanisms by which hfNCSCs promote nerve regeneration, including multipotent differentiation, neurotrophic factor secretion, and immunomodulation.
Figure 2: A schematic diagram illustrating the mechanisms by which stem cell-derived exosomes promote nerve repair by delivering bioactive molecules (e.g., miRNAs, proteins) to target cells.
This dataset directly supports the research presented in the manuscript titled "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury", which is under review at Stem Cells International. The DOI for the article will be added upon acceptance. These figures and tables are integral components of the article.