Nickel-Catalyzed Domino Reaction of α‑Aryloxyacetonitriles with Arylboronic Acids: Synthesis of 2‑Aroylbenzo[b]furans

We disclose the first catalytic domino reaction of α-(2-formylaryloxy)acetonitriles with arylboronic acids, yielding a range of 2-aroylbenzo[b]furans with yields of up to 93%. Ni(acac)2 serves as an effective dual catalyst. The protocol is also applicable to α-(2-acetylphenoxy)acetonitrile, giving rise to 3-methyl-2-aroylbenzo[b]furans. This domino process is efficient, additive-free, and compatible with a variety of aryl boronic acids, including those with CF3, NO2, CN, and CO2Me groups. Mechanistic studies highlight the dual activation facilitated by the nickel catalyst.