Glioma International Case Control Study (GICC)

The main goals of the GICC Study were: 1) to identify novel genetic risk variants for glioma, as well as validate variants implicated by previous genome-wide association studies of glioma; and 2) to explore biologically relevant gene-gene and gene-environment interactions in glioma susceptibility. The GICC Study includes participants from the following centers: Brigham and Women's Hospital (Boston, Massachusetts), Case Western Reserve University (Cleveland, Ohio), Columbia University (New York, New York), the Danish Cancer Society Research Centre (Copenhagen, Denmark), Duke University (Durham, North Carolina), the University of Texas MD Anderson Cancer Center (Houston, Texas), Memorial Sloan Kettering Cancer Center (New York, New York), the Mayo Clinic (Rochester, Minnesota), NorthShore HealthSystem (Chicago, Illinois), Umea University (Umea, Sweden), the University of California, San Francisco (San Francisco, California), the University of Southern California (Los Angeles, California), and the Institute of Cancer Research (London, United Kingdom).]]>
Inclusion Criteria: Case recruitment took place between 2010 and 2013. Eligibility criteria for cases were as follows: Diagnosis of histologically confirmed, supratentorial, intracranial glioma (World Health Organization (WHO) grades II-IV): fibrillary astrocytoma (International Classification of Diseases, Ninth Revision, code 9420/3), protoplasmic astrocytoma (code 9410/3), gemistocytic astrocytoma (code 9411/3), oligodendroglioma (code 9450/3), oligoastrocytoma (code 9382/3), anaplastic astrocytoma (code 9401/3), anaplastic oligodendroglioma (code 9451/3), anaplastic oligoastrocytoma (code 9382/3), or glioblastoma (code 9440/3) Age 18-80 years at diagnosis Ability to speak the local language Cases were recruited within 1 year of diagnosis and consented to participation at their clinic visits. Blood/saliva samples and interviews were obtained or scheduled at that time. Reprinted from Amirian et al, Am J Epidemiol. 2016 Jan 15; 183(2): 85-91 ]]>