Activated AR binds RUNX2

Androgen receptor (AR), activated by binding to androgens, forms a complex with RUNX2 (presumably associated with CBFB) in the nucleus. AR inhibits transcriptional activity of RUNX2, which may underlie AR-mediated attenuation of bone turnover. RUNX2 may play a tumor suppressor role in prostate cancer (Baniwal et al. 2009).<p>The complex of RUNX2 and AR is implicated in stimulation of the PSA gene transcription in response to TGF-beta signaling, but further experimental validation is needed (van der Deen et al. 2010).

雄激素受体（AR）在结合雄激素后，于细胞核内与RUNX2（可能关联于CBFB）形成复合物。AR可抑制RUNX2的转录活性，这可能是AR介导的骨转换降低的潜在机制。RUNX2可能在前列腺癌中发挥抑癌基因的作用（Baniwal等，2009年）。RUNX2与AR的复合物在TGF-β信号通路刺激PSA基因转录过程中被涉及，但需要进一步的实验验证（van der Deen等，2010年）。