eQTLs with a nominally significant GWAS p value in the replication data.

Independent eQTLs are based on LD-based SNP clumping. For each locus, the clump index SNP (with the lowest p value) is shown. For the GWAS replication results, Bonferroni corrected p values are given for the testing of 322 clumps. SNP association results in the joint GWAS data were based on a total of 3,568 ALS patients and 10,163 controls. For the eQTL direction of effect, ‘+’ means the SNP minor allele was associated with increased expression levels, ‘–’ means decreased gene expression. Chr, chromosome; LD, linkage disequilibrium; GWAS, genome-wide association study; OR, odds ratio; p bonf., Bonferroni corrected p value; n.s., not significant; eQTL, expression quantitative trait locus.