A CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
收藏国家人口健康科学数据中心2026-06-06 收录
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CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
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北京蛋白质组研究中心创建时间：
2026-03-03
