RNA Synthesis Precision is Regulated by Preinitiation Complex Turnover

TATA-binding protein (TBP) nucleates the assembly of the transcription preinitiation complex (PIC), and although TBP can bind promoters with high stability in vitro, recent results establish that virtually the entire TBP population is highly dynamic in yeast nuclei in vivoTATA盒结合蛋白（TATA-binding protein，TBP）可介导转录前起始复合物（transcription preinitiation complex，PIC）的组装成核；尽管TBP在体外能够以高稳定性结合启动子，但最新研究证实，酵母细胞核内几乎所有的TBP群体均呈现高度动态的特性。