Independence of the protective class I haplotype from DRB1*15 demonstrated in two ways.

Counts are made in number of chromosomes carrying the haplotypes estimated in UNPHASED within the cohort. “Haplotype +” was all chromosomes with both A*02, C*05 and B*12 disregarding the DRB1 locus, “Haplotype –”were all chromosomes that did not have all three allele groups (A*02, C*05 and B*12) at once, still disregarding DRB1. “DRB1*15+” was all chromosomes carrying DRB1*15 disregarding class I allele groups and vice versa for the “DRB1*15 –”.*) Odds ratio for the class I haplotype within DRB1*15 positive and negative haplotypes respectively.**) Odds ratio for DRB1*15 within the class I haplotype and class I haplotype negative respectively. Note: Class I haplotype negative chromosomes can carry parts of the protective haplotype (i.e. A*02 but in that case not C*05 and/or B*12).