Raw data related to: Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson's Disease

Fig. 6A,B,C – Effect of caspase-3 activation on synaptic responses to sustained electrical stimulation in PINK1-/- MSNs.

(A) Time-course of synaptic responses to sustained stimulation (30 Hz, 30 s) in PINK1+/+ MSNs. Current peak amplitudes are reported as mean SEM. In the inset, the first and last EPSC from a representative experiment are shown. (B) Time course of synaptic responses in PINK1+/- MSNs shows a similar response to sustained stimulation. (C) In PINK-/- MSNs, we observed faster depression kinetics after the 12th stimulus.