Histone H3.3 and its proteolytically processed form drive a cellular senescence program
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
In this study, we have uncovered novel proteolytic processing of the histone H3 tail in senescence models in primary fibroblasts and melanocytes. Cleavage of H3 tail occurs at two distinct residues and is mediated by Cathepsin L. We show that variant H3.3 is preferentially cleaved, and that cleaved histones are associated with chromatin and incorporated into nucleosomes. We also found that the histone chaperone ASF1a is required for chromatin incorporation of the cleaved histone species. Further, we show that overexpression of cleaved H3.3 induces a senescence program in fibroblasts in the absensence of oncogenic signaling.
提供机构：
Icahn School of Medicine at Mount Sinai
创建时间：
2022-02-20
