Rapid inference of Pseudomonas aeruginosa antibiotic resistance and susceptibility by clinical metagenomic sequencing

Growing concerns about the rising of antibiotic-resistant bacteria call for rapid detection of drug resitance in clinical samples. Current antibiotic susceptibility testing (AST) largely relies on time-consuming culture-based methods, which may cause a delay for patient treatment and increase mortality.accurate alternative AST assay is a critical need for optimization of current diagnostics.