Microbiome in Lower Respiratory Tract of community-acquired pneumonia with or without COPD

Pulmonary physicians may choose a different empirical antibiotic therapy when faced with a community-acquired pneumonia(CAP) patient concomitant with chronic obstructive pulmonary disease(COPD) compared to a CAP patient without COPD. However, the detailed microbiome distribution in lower respiratory tract of CAP with COPD or CAP without COPD was unknown. So we used metagenomic next generation sequencing(mNGS) to explore the microbiome differences between the two groups.