One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels–Alder Reaction
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/One_Step_Semisynthesis_of_a_Segetane_Diterpenoid_from_a_Jatrophane_Precursor_via_a_Diels_Alder_Reaction/2071429
下载链接
链接失效反馈官方服务：
资源简介：
A novel
segetane diterpenoid (1) and four jatrophane diterpenoids
(2–5) were isolated from an acetone
extract of Euphorbia peplus. Due to quantity limitations,
we prepared 1 via a Diels–Alder reaction, an approach
motivated by this compound’s biosynthetic pathway and successfully
performed X-ray analysis of 1. Furthermore, in an in vitro activity test, 1 exhibited moderate
anti-inflammatory activity, whereas both its precursor (2) and the relevant intermediate (2a, IC50 = 1.56 μM) exhibited significant anti-inflammatory activity.
创建时间：
2016-02-04
