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Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor aficamten

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Protein Data Bank Japan2024-09-11 更新2026-04-19 收录
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https://pdbj.org/mine/summary/9f6c
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Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor aficamten Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-7, ... Authors: Robert-Paganin, J, Hartman, J.J, Morgan, B.P, Malik, F.I, Houdusse, A. Deposit date: 2024-05-01 Release date: 2024-09-04 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy. Nat Cardiovasc Res, 3, 2024
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2024-05-01
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