Structure of RORgt in complex with a novel isoquinoline inverse agonist.
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Structure of RORgt in complex with a novel isoquinoline inverse agonist. Descriptor: (1R)-N-(4-tert-butyl-3-fluorophenyl)-6-methoxy-2-[(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxamide, (4S)-2-METHYL-2,4-PENTANEDIOL, Nuclear receptor ROR-gamma Authors: Skene, R.J, Hoffman, I. Deposit date: 2017-11-29 Release date: 2018-03-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.18 Å) Cite: Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist. J. Med. Chem., 61, 2018
创建时间：
2017-11-29
