Clinical chemistry parameters of VEGF-A and CX-treated rabbits.

Serum markers of toxicity and inflammation were assayed using blood samples from the rabbit at the beginning (day 0) and end of the study (day 6). Changes in serum levels of the indicated markers were analyzed for statistically significant changes at day 6 between CX and vehicle-treated animals. In CX-treated rabbits there were significant increases of alkaline phosphatase, alanine aminotransferase and total bilirubin indicating liver stasis and toxicity. There was also an increase in creatinin after compound X treatment, suggesting renal toxicity.
Compound X: CX, S: serum, ALP: alkaline phosphatase, ALT: alanine aminotransferase, TB: total bilirubin, CRP: C-reactive protein, LD: Lactate dehydrogenase. Analyte levels are given +/− standard deviatio n. Reference values for rabbit are from Hewitt et al., and Ypsilantis et al.[48], [49]. Significance level using students t-test.
* =  <0.05,
** = P<0.01.
*** = P<0.001.