Effect of hepatic depletion of Ftcd on gene expression during hepatocarcinogenesis in DEN-induced and untreated C57BL/6 mice

To investigate the global function of Ftcd in the regulation of hepatocarcinonegesis, we established DEN-induced or untreated liver-specific Ftcd knockout(referred as Ftcd LKO) murine model in which Ftcd has been knocked out by loxp/alb-cre system, take the wildtype(referred as WT) mice as control. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different Ftcd LKO mice and 6 different WT mice at 12 months after DEN treatment, as well as RNA-seq of 3 different 12-month-old Ftcd LKO and WT mice. Comparative gene expression profiling analysis of RNA-seq data for tumourous tissues or nontumorous liver tissues from Ftcd LKO mice or WT littermates with or without DEN treatment