Effects of chemokine receptor variants on AIDS progression.

1The rate of progression to AIDS (1987 CDC definition [66]) were calculated with the Cox proportional hazards model. The analyses were adjusted for age, sex and covariates CCR5-Δ32, and four HLA alleles (Class I homozygosity, B27, B35Px and B57). CI (confidence interval), RH (relative hazard);2After including eigenvector values for the top two principle components as a covariate in the Cox regression analysis to control for potential population stratification. Eigenvector values were obtained from Eigensoft program by performing a principal component analysis of 700,022 SNPs in the previous GWAS study [71];3The adjusted p-values further correcting for multiple testing of 7 chemokine receptor variants using the Holm's step-down Bonferroni method;4CCR5-2459A (rs1799987, Tag SNP of CCR5-P1, previously shown to be associated with AIDS in a recessive model [15];5With adjustment of CCR5-2459A.