Transcriptomic analysis of the distal colon of wild type C57BL/6N mice and mice harboring a mutation (S839I) in Gucy2c

A novel mouse harbouring a mutation in receptor guanylyl cyclase C (Gucy2c) that is equivalent to that seen in patients with Familial GUCY2C syndrome was established. Since patients are susceptible to colitis-like disease and IBD, RNAseq was performed on the distal colon in these mice to identify global transcriptome changes that arise as a consequence of this mutation Gucy2c.