PRS predicting cognitive decline at the most predictive threshold in each cohort separately and following meta-analysis.

“AD Risk” is the predictive ability of PRS derived from Schwartzentruber et al. 2021. “Progression” is the predictive ability of PRS derived from the progression GWAS reported here; ie, the GSK GWAS is used to construct PRS for the WUSTL cohorts, and a meta-analysis of the 3 WUSTL cohorts is used to construct PRS for the GSK cohort.