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Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution

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Protein Data Bank Japan2024-10-23 更新2026-03-21 收录
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Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... Authors: Borodovsky, A, Wang, Y, Deng, N, Ye, M, Stephen, T.L, Goodwin, K, Goodwin, R, Strittmatter, N, Shaw, J, Sachsenmeier, K, Clarke, J.D, Hay, C, Reimer, C, Andrews, S.P, Brown, G.A, Congreve, M, Cheng, R.K.Y, Dore, A.S, Mason, J.S, Marshall, F.H, Weir, M.P, Lyne, P, Woessner, R. Deposit date: 2018-06-15 Release date: 2019-06-26 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity J Immunother Cancer, 2020
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2018-06-15
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