Comparison of protection after different methods of pulmonary infection with Mtb.
收藏Figshare2015-12-02 更新2026-04-29 收录
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BALB/c mice were immunized with BCG, or primed with BCG and 8 weeks later boosted with Ad85A given intradermally (BA i.d.) or intranasally (BA i.n.). Naïve mice were used as controls. Mice were challenged with Mtb 4 weeks after the last immunization intranasally (I.N.), intratracheally (I.T.) or by aerosol. Deposition in the lungs was measured 24 h after challenge and was ∼1000 CFU per lung after I.N., 620 CFU after I.T. and 880 CFU after aerosol Mtb challenge. Mice were sacrificed 4 weeks later and lungs and spleen CFU enumerated. Data represent the mean +/− SD from 6–8 mice per group.*p**p
创建时间：
2015-12-02
