Investigating the effect of insulin administration on the brain of Alzheimer's disease mice

A correlation between Alzheimer's disease (AD), insulin resistance, and glucose metabolism has been postulated. Beyond its role in blood sugar regulation, insulin exhibits potential neuroprotective effects, and its resistance in the brain may be linked to accelerate cognitive aging and AD. Pilot clinical studies reveal that insulin administration improves memory performance; it has been hypothesized that insulin acts by enhancing the synaptic plasticity and conformationally disrupting the brain amyloid beta plaques. Thus, this study aims to evaluate the effects of insulin administration - a candidate therapeutic intervention for dementia - on the structure of amyloid beta plaques, the neuronal and capillary network and on the surrounding microenvironment in the brain of AD mice by comparing insulin-treated AD mice with untreated AD mice and healthy wild-type mice as controls.