Effect sizes, expressed as percentage of the total variance explained by the respective factor, on pain thresholds.

#MAF: Observed minor allelic frequencies. “Minor” refers to the allele reported to be minor in gene databases. When its reported allelic frequency is close to 50%, it can happen that the “minor” allele has a frequency >50% in the actual cohort. We nevertheless preserved the denomination “minor” to be consistent with SNP databases.In the case of the genetic factors, the reference and the observed allelic frequencies are given, and the dominant hereditary model was used, i.e., assigning heterozygous subjects to the group of wild-type carriers. The effect sizes are given in italic letters when they were larger than those of gender, and in bold letters when exceeding, arbitrarily chosen, 5%.