E3 ligase Cbl-b in complex with a triazolone core inhibitor (compound 1)

E3 ligase Cbl-b in complex with a triazolone core inhibitor (compound 1) Descriptor: 8-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-3-[[(3~{S})-3-methylpiperidin-1-yl]methyl]-5-(trifluoromethyl)-1$l^{4},7,8-triazabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... Authors: Schimpl, M. Deposit date: 2024-06-17 Release date: 2024-07-31 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (1.786 Å) Cite: Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design. J.Med.Chem., 67, 2024