Additional file 13 of Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

Additional file 13 Overview of unique proteins detected and quantified within temporal cortical tissues for AD and unique proteins detected and quantified within temporal cortical tissues for both AD and the FTD-MAPT subtype. Proteins were selected using quality filtering on peptide level (q ≤10-3 in at least 50% of samples per group, i.e. NDC or AD). For every protein, the raw fold change and raw p-value are given for the statistical comparison between NDC and AD, and NDC and FTD-MAPT. In addition, columns are included which note whether a protein has passed statistical multiple testing comparison (q < 0.05) and whether differential protein expression is in a similar direction in AD and FTD-MAPT.

额外文件13概述了阿尔茨海默病（AD）和FTD-MAPT亚型在颞叶皮质组织中检测和定量到的独特蛋白质，以及同时在AD和FTD-MAPT亚型中检测和定量到的独特蛋白质。蛋白质的筛选基于肽水平上的质量过滤（每组样本中至少50%的样本的q值≤10^-3，即NDC或AD）。对于每一种蛋白质，均提供了原始倍数变化和原始p值，以进行NDC与AD以及NDC与FTD-MAPT之间的统计分析。此外，还包括了备注蛋白质是否通过统计多重检验比较（q < 0.05）以及差异蛋白质表达在AD和FTD-MAPT中是否呈现相似方向的列。