[TEST] Dataset

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia caused by mutations in the ryanodine receptor type 2 (RyR2). CPVT is characterized by exercise/stress-induced syncope and cardiac arrest in the absence of resting ECG and structural cardiac abnormalities. We present a database of 1008 CPVT patients that includes information regarding genetic diagnosis, location of the mutation in RyR2, available mutant channel functional data, clinical history and presentation, and treatment strategy. Data analyses revealed that patients most often experienced exercise-induced syncope in their early teenage years but the diagnosis of CPVT took a decade. Mutations located near key regulatory sites in the channel were associated with earlier onset of CPVT symptoms including sudden cardiac death. Publication databases, including PubMed, Embase, and Scopus, were searched for articles written from their onset through October 2020. Keywords to narrow our search results were used, including, but not limited to, catechol polymorphic ventricular tachycardia, channelopathic cardiac diseases, cardiac arrythmias, sudden cardiac death, syncope, and RyR2. The database was designed primarily to include binary data to facilitate future analyses.