Supplementary materials of Systematic investigation of gengetically determined plasma and urinary biomarkers to identify potential detection and intervention targets for vascular calcification

This dataset contains Supplementary Tables 1–11 associated with the manuscript “Systematic investigation of genetically determined plasma and urinary biomarkers to identify potential detection and intervention targets for vascular calcification” (Liu et al., submitted to Renal Failure; preprint DOI: 10.64898/2026.07.31.26359444). The tables support a two-sample Mendelian randomization (MR) study investigating causal relationships between genetically determined plasma and urinary biomarkers and vascular calcification (VC), and the mediating effects of modifiable risk factors. The dataset includes: Supplementary Table 1: Overview of GWAS data sources, sample sizes, populations, and original study references. Supplementary Table 2: Instrumental variables used for plasma and urinary biomarkers. Supplementary Table 3: Complete MR results for biomarkers and VC. Supplementary Table 4: Sensitivity analyses for biomarkers. Supplementary Table 5: Instrumental variables used for VC. Supplementary Table 6: Reverse MR results for VC and biomarkers. Supplementary Table 7: Sensitivity analyses for alkaline phosphatase (ALP). Supplementary Table 8: Instrumental variables used for modifiable risk factors. Supplementary Table 9: Univariable MR results for risk factors and VC. Supplementary Table 10: Univariable MR results for risk factors and biomarkers. Supplementary Table 11: Mediation analysis results. All analyses are based on publicly available GWAS summary statistics. No individual-level or identifiable human data are included. The original GWAS data were obtained from the UK Biobank, the EMBL-EBI GWAS Catalog (accession numbers GCTS90278455 and GCTS90278456), the FinnGen database, and the MRC IEU OpenGWAS database, as detailed in Supplementary Table 1. These tables are provided to support reproducibility and transparency of the study findings.