High fat diet induced dysregulation in adipose tissue microRNAs. High fat diet induced dysregulation in adipose tissue microRNAs

During obesity progression differential expression of microRNAs (miRs) play a role in effector (Teff) functions. A set of high fat diet adipose tissue derived immune cell miRs shows profound upregulation or downregulation in the expression profile as compared to normal diet. Overall design: our preliminary data indicates that high fat diet down-regulates adipose resident T cell miRs-10a, -125b, and -1247 and suggesting that mimicking these miRs might be of therapeutics for the obesity and metabolic syndrome.