The expression profile of miRNA in the testis of STZ-induced diabetic rats

The number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual dysfunction. We thus explored the role of miRNAs in diabetic testicular damage, and revealed that they could serve as effective prevention and treatment therapeutic targets.Streptozotocin (STZ) was used to generate a rat model of type 2 diabetes. Rat testicular tissues were used for miRNA sequencing. we identified 19 differentially expressed miRNAs in the testes of diabetic rats.全球糖尿病患者人数正逐年攀升。糖尿病性睾丸损伤可引发精子发生障碍与性功能障碍。为此，本研究围绕微小核糖核酸（miRNAs）在糖尿病性睾丸损伤中的调控作用展开探索，并证实其可作为有效的防治靶点。本研究采用链脲佐菌素（Streptozotocin, STZ）构建2型糖尿病大鼠模型，提取大鼠睾丸组织进行微小核糖核酸测序，最终在糖尿病大鼠的睾丸组织中鉴定出19种差异表达的微小核糖核酸。