Summary of EC50s from experiments measuring IP1 accumulation and ERK1/2 phosphorylation.
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HEK293 cells were transiently transfected with the WT CaSR or disease-associated CaSR mutants. Cells were then treated with various levels of [Ca2+]o. The EC50s of [Ca2+]o-IP1 responses and the -[Ca2+]o-ERK1/2 phosphorylation activity responses were obtained from curve fitting using the Hill equation as mentioned in Method. # indicates significance with respect to wild type CaSR, p* indicates significance with respect to the corresponding mutants in the absence of L-Phe, pSummary of EC50s from experiments measuring IP1 accumulation and ERK1/2 phosphorylation.
创建时间：
2015-12-02
