Mechanisms of Sinoatrial Node Dysfunction in Heart Failure with Preserved Ejection Fraction

RNA sequencing from sinoatrial node tissue was performed to identify transcriptomic changes in Dahl salt-sensitive rats fed with normal salt diet (0.4% NaCl, control group) or high-salt diet (8% NaCl, HFpEF group) for 11 weeks. Transcriptomic profiling revealed numerous changes in multiple disease-associated genes in HFpEF, which is functionally related to the observed physiological impairments and structural remodeling. Overall design: Transcriptome changes in sinoatrial node from control and HFpEF animals