Genome-wide identification of E2f3 and Myc DNA binding sites in normal and Rb-deficient intestines

To explore how Myc and E2f3 might coordinate gene expression programs that drive normal cell cycles in wild type intestines and ectopic cell cycles in Rb-deficient small intestines, we compared Myc and E2f3 chromatin occupancy in these tissues. Overall design: Examination of DNA binding of 2 transcription factors (E2f3 and Myc) in normal and Rb-deficient villus cells.