NFS1
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1350532
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资源简介：
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
铁硫簇对于众多细胞酶的功能至关重要。该基因编码的蛋白质通过从半胱氨酸中移除硫原子，从而向这些簇提供无机硫，并在这一过程中生成丙氨酸。该基因利用不同的编码框架起始位点来生成线粒体形式和细胞质/核形式。替代起始位点的选择由细胞质pH值决定。编码的蛋白质属于依赖吡哆醛磷酸的V类氨基酸转移酶家族。此外，已描述了可变剪接的转录变体。[由RefSeq提供，2010年11月]
提供机构：
Rat Genome Database
