Shared Genetic Architecture of Posttraumatic Stress Disorder with Cardiovascular Imaging, Risk, and Diagnoses

Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Here we provide GWAS summary statisticts of 13 CV phecodes (and CV behaviour) meta-analyzed from MVP and UKBB, that were generated in this study. Phe_244 Hypothyroidism Phe_244_4 Hypothyroidism NOS Phe_250 Diabetes mellitus Phe_250_2 Type 2 diabetes Phe_278 Overweight, obesity and other hyperalimentation Phe_278_1 Obesity Phe_401 Hypertension Phe_401_1 Essential hypertension Phe_411_4 Coronary atherosclerosis Phe_411_8 Other chronic ischemic heart disease, unspecified Phe_418 Nonspecific chest pain Phe_427 Cardiac dysrhythmias Phe_427_2 Atrial fibrillation and flutter Slppm Waking up in the middle of the night (MVP) + Insomnia (Watanabe, K. et al 2022) Slpfall Difficult in falling asleep (MVP) + Insomnia (Watanabe, K. et al 2022) The compressed files have tab delimiter, with headers listed as follows. CHR - chromosome number BP - base pair (hg19) SNP - rsids A1 - effect allele A2 - non-effect allele FREQ - frequency of effect allele P - pvalue N - total sample size BETA - effect size SE - standard error