GonzalezHeydrich1994_HPAaxisRegulation_CortisolProduction

This a model from the article:
A computer simulation of the hypothalamic-pituitary-adrenal axis.

Gonzalez-Heydrich J, Steingard RJ, Kohane I. Proc Annu Symp Comput Appl Med Care
1994;:1010 7949852
,
Abstract:

This paper describes the construction of a computer model that simulates the
hypothalamic-pituitary-adrenal axis (HPA axis) regulation of cortisol
production. It is presented to illustrate the process of physiological modeling
using standard "off the shelf" technologies. The model simulates components of
the HPA axis involved in the continuous secretion and elimination of cortisol,
adrenocorticotropin (ACTH), and corticotropin releasing hormone (CRH). The
physiological relations of these component pieces were modeled based on the
current knowledge of their functioning. Rate constants, half lives, and receptor
affinities were assigned values derived from the experimental literature. At its
current level of development the model is able to accurately simulate the
timing, magnitude and decay of the ACTH and cortisol concentration peaks
resulting from the ovine-CRH stimulation test in normal and hypercortisolemic
patients. The model will be used to predict the effects of lesions in different
components of the HPA axis on the time course of cortisol and ACTH levels. We
plan to use the model to explore the experimental conditions required to
distinguish mechanisms underlying various disorders of the HPA axis,
particularly depression. Efforts are currently underway to validate the model
for a large variety of normal and pathological perturbations of the HPA axis.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Gonzalez-Heydrich J, Steingard RJ, Kohane I. (1994) - version02

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