The effect of Rev-erba on gene expression in mouse brain

A third of patients with epilepsy are refractory to drug treatment, necessitating a more complete understanding of epileptogenic mechanisms and novel therapeutics. we uncover a critical role for Rev-erba, a ligand-responsive clock component, in circadian regulation of epileptic seizures. In vivo, small-molecule antagonism of Rev-erba alleviates acute and chronic seizures in mouse models. Thus, targeting Rev-erba may represent a promising mechanism for management of epileptic seizures.